Authors
Baleev M.S.
City Clinical Hospital №7 named after E.L. Berezov, Nizhny Novgorod
Abstract
Background: The relevance of the problem of intestinal insufficiency in patients with consequences of spinal injury is becoming increasingly interesting in the practice of a multidisciplinary team of doctors dealing with this cohort of patients. Neurogenic dysfunction of the intestinal tract leads to many pathological conditions associated with intestinal insufficiency, but the acute period of traumatic spinal cord disease is largely characterized by hypoproteinemia, lipoproteinemia, vitamin deficiency, deficiency of minerals, electrolyte compounds, amino acids, mono- and disaccharides. At the same time, the processes occurring in the intestinal wall membranes in patients with consequences of spinal injury have not been sufficiently studied to date.
Objective: To study the features of metabolic processes in the mucous membrane of the small intestine in the first hours after spinal injury.
Materials and methods: In an acute spinal cord injury experiment involving laboratory animals – Wistar rats (n = 20), the dynamics of metabolism in the small intestinal mucosa was studied.
Results: The mucous membrane of the small intestine in the acute period of spinal injury had a hypercatabolic direction of metabolic processes, characterized by a decrease in the average fluorescence lifetime (tm) and a progressive increase in the relative contributions of the short and long attenuation components (a1/a2).
Conclusion: The acute period of traumatic spinal cord injury is characterized by metabolic disturbances in the small intestinal mucosa. A decrease in the average weighted survival time (tm) and an increase in the percentage contribution of the short component (a1) at each time interval under study confirms the hypercatabolic and hypermetabolic direction of metabolic processes without significant histological changes in the small intestinal mucosa. The results obtained can serve as a starting point in understanding the necessary composition, caloric content, and time of administration of enteral nutritional mixtures used to maintain homeostasis in patients with spinal cord injury.
Keywords: spinal cord injury, catabolism, metabolism, sarcopenia, energy metabolism FLIM.
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