Authors
Umarov G.M., Shestakov E.A., Gusarov V.G., Melnichenko V.Ya., Fedyk O.V., Zhiburt E.B.
Pirogov National Medical and Surgical Center, Moscow
Abstract
The article presents a clinical observation of a 41-year-old female patient with lymphoma undergoing autologous stem cell transplantation is presented. Evidence-based red blood cell and platelet transfusion strategies contributed to the successful treatment of this patient with profound thrombocytopenia after stem cell transplantation. It is demonstrated that thromboelastography can be used in diagnostic monitoring of platelet transfusion efficacy.
Keywords: thromboelastogram, platelets, hemostasis, red blood cells, blood transfusion, clinical case.
References
1. Shevchenko YL, Karpov OE, Zhiburt EB. Blood transfusion: history and modernity (on the 100th anniversary of blood transfusion in Russia)). Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2019; 14(4): 4-11. (In Russ.) doi: 10.25881/BPNMSC.2020.29.78.001.
2. Tantry US, Hartmann J, Neal M.D. et al. The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation. Platelets. 2022; 33(4): 520-530. doi: 10.1080/ 09537104.2021.1961709.
3. Zhiburt EB, Madzaev SR, Shestakov EA. Patient’s blood management. 2-e izdanie. M.: Nacional’nyj mediko-hirurgicheskij centr imeni N.I. Pirogova, 2021. (In Russ.)
4. Zhiburt EB. Pediatrics transfusiology. Moscow: Geotar-Media, 2023. 344 p. (In Russ.)
5. Zarubin MV, Gubanova MN, Gaponova TV. et al. Ensuring the efficiency and safety of platelet transfusion. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2016; 11(3): 118-125. (In Russ.)
6. Zhiburt EB, Madzaev SR, Shestakov EA. How to transfuse blood. M.: Nacional’nyj mediko-hirurgicheskij centr imeni N.I. Pirogova, 2018. (In Russ.)
7. van Baarle FLF, van de Weerdt EK, van der Velden WJFM, et al. Predictors of the corrected count increment after platelet transfusion, a secondary analysis of the PACER randomized controlled trial. Am J Hematol. 2023; 98(11): E305-E308.
8. Pokhabov DS, Shestakov EA, Fedyk OV, et al. Thromboelastography and coagulogram in a multidisciplinary clinic. Thromboz, hemostaz i reologiya. 2023; (3): 38-44. (In Russ.) doi: 10.25555/THR.2023.3.1067.
9. Kuznetsov SI, Shestakov EA, Gusarov VG. et al. Blood transfusion in a COVID-19 hospital. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2021; 16(4): 74-77. (In Russ.) doi: 10.25881/20728255_2021_16_4_74.
10. Zhiburt EB, Shestakov EA, Madzaev SR, Shalygin LD. Hemostasis and blood transfusion: randomized trials in 2023. Thromboz, hemostaz i reologiya. 2024; (2): 13-18. (In Russ.) doi: 10.25555/THR. 2024.2.1094.
11. Zhiburt EB, Madzaev SR. Platelets collection and transfusion. M.: RAEN, 2013. 376 p. (In Russ.)
12. Zhiburt EB, Madzaev SR, Shestakov EA. Medical and cost-effectiveness of a restrictive blood transfusion strategy. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2015; 10(1): 100-102. (In Russ.)
13. Glover R, Yeboah B, Vassallo RR, et al. It is time to eliminate the one-hour corrected count increment in the diagnostic workup of platelet transfusion refractoriness. Transfusion. 2025; 65(8): 1553-1555. doi: 10.1111/trf.18327.
14. Pati I, Masiello F, Pupella S, et al. Efficacy and Safety of Pathogen-Reduced Platelets Compared with Standard Apheresis Platelets: A Systematic Review of RCTs. Pathogens. 2022; 11(6): 639. doi: 10.3390/pathogens11060639.
15. Zhiburt EB, Khamitov RG, Shalygin LD, et al. Inactivation of pathogens in pediatric transfusiology. Thromboz, hemostaz i reologiya. 2022; 2: 33-40. (In Russ.)
16. Khamitov RG, Pokhabov DS, Turaeva RR et al. Inactivation of pathogens at the AABB-2024 conference. Gematologiya, transfuziologiya, Vostochnaya Evropa. 2025; 11(1): 103-113. (In Russ.)
17. Pokhabov DS, Kolesov AA, Ayupova RF, et al. Improving hardware platelet apheresis. Medicinskaya Tehnika. 2023; 3: 42-44. (In Russ.)
18. Chemodanov IG, Kuznetsov SI, Averyanov EG et al. Platelet apheresis: characteristics of donations and obtained products. 2019; 20(4): 256-264. (In Russ.)
19. Zhiburt EB, Chemodanov IG, Averyanov EG, Kozhemyako OV. Sustainability of blood services. Bjulleten’ Nacional’nogo nauchno-issledovatel’skogo instituta obshhestvennogo zdorov’ja imeni N.A. Semashko. 2017; 7: 17-24. (In Russ.)
20. Zhiburt EB, Khamitov RG, Shestakov EA. et al. On the protocol of massive transfusion. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2025; 19(4): 136-142. (In Russ.)


