Authors
Kolotilina M.A.1, Martishina E.E.2, Sukhorukov R.V.2, Tuzov V.V.3, Vinnikova M.D.1
1 Ural state medical university, Yekaterinburg
2 Volgograd state medical university, Volgograd
3 Saint Petersburg state pediatric medical university, Saint Petersburg
Abstract
Rationale: With the pandemic caused by SARS-CoV-2, accurate identification of patients at high risk for complications has become a key factor in ensuring positive treatment outcomes. A promising technique to facilitate such identification is the use of biomarkers that can predict complications and severity of COVID-19 course.
Objective: The purpose is to evaluate the prognostic significance of various biomarkers in individuals with COVID-19 and to determine the value of developing standardized protocols for monitoring these indicators under pandemic conditions.
Methods: For the analysis, we reviewed studies on the role of biomarkers such as C-reactive protein, D-dimer, ferritin, lactate dehydrogenase and troponins in predicting complications in patients with COVID-19. Sources used were international peer-reviewed journal publications, clinical trial results, and meta-analyses available in scientific databases.
Results: Elevated levels of biomarkers such as C-reactive protein, D-dimer, ferritin, lactate dehydrogenase and troponins correlate with a high risk of acute complications, making them useful tools for monitoring. The common thresholds for assessing severity of illness will reduce data variability and improve comparability of results between healthcare providers.
Conclusion: The data highlights the importance of biomarkers for monitoring patients with COVID-19 and the need to develop standardized protocols to improve prognostic accuracy. Prospects for the use of biomarkers in adaptive critical care and resuscitation are important means to optimize patient outcomes and further research.
Keywords: COVID-19, biomarkers, clinical indicators, complication prediction, SARS-CoV-2, diagnostic standardization, mortality, intensive therapy, C-reactive protein, D-dimer.
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