Authors
Sazonenkov m.A.1, 2, Moskalev A.S.1, Tatarintsev A.M.1, Ismatov h.H.2, Moskaleva d.D.2
1 Belgorod Regional Clinical Hospital, Belgorod
2 Belgorod National Research University, Belgorod
Abstract
Background. Mitral valve disease is one of the main diagnoses operated on in cardiac surgery at the present time. There are a number of etiological causes of mitral valve disease that require correction. The distribution of etiologies, methods of valve correction, and the results of operations change with the growth of surgical practice.
Purpose. To study all cases of surgical treatment of mitral valve disease in the cardiac surgery department of Belgorod for the period of 2015-2024. To identify the main pathologies, their distribution, and changes in surgical techniques over the selected period.
Methods. In the cardiac surgery department of the St. Joasaph Regional Hospital, an average of 490 heart surgeries were performed per year over the selected 10-year period. Of these, 51–84 cases involved surgical correction of mitral valve defects. In total, 582 cases of mitral valve defects were treated during the period from January 1, 2015 to December 31, 2024. The etiology of the defect is diverse: degenerative mitral valve insufficiency (DMI), chronic rheumatic disease, secondary damage in coronary artery disease (CAD), infectious endocarditis (IE), hypertrophic obstructive cardiomyopathy (HOKM). The method of correction was taken into account: valve prosthesis or reconstruction.
Results. The first place in the etiology of the defect was occupied by degenerative insufficiency of the MK, the second – CRBS, the third – secondary damage of the valve in CAD, the fourth – IE, the fifth – HOKM. During the selected period, the proportion of degenerative mitral insufficiency (DMI) was 40.5% to 64.5% per year, with an average of 50.86%. The proportion of operated CHF was 6.3% to 23.6%, with an average of 17.52%. Ischemic mitral insufficiency occurred in 30.8% to 5.7%, with an average of 13.92%. Operations for infectious endocarditis were performed in 3.2% to 13.6% of cases, with an average of 9.62%. Corrections of the mitral valve defect in HCMF were performed in 1.9% to 13.4% of cases, with an average of 8.06%. During the follow-up period, there was a decrease in the frequency of correction of mitral valve insufficiency in IHD and an increase in the frequency of correction in CRBS. The share and variety of reconstructive techniques used have increased significantly.
Conclusion. During the selected period of time 2015–2024, the number and proportion of cases of surgical correction of mitral valve disease remain relatively constant. The proportions of the frequency of etiologies of operations on the MK obtained by us correspond to the global practice. The expansion of the frequency of use and complexity of the valve reconstructions used did not lead to a decrease in the quality of the results.
Keywords: mitral valve lesion, etiology, methods of surgical correction, reconstructive operations.
References
1. Association of Cardiovascular Surgeons of Russia. All-Russian Scientific Society of Cardiology. Clinical recommendations. Mitral insufficiency. Moscow, 2020. (In Russ.)
2. Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease. A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021; 143: e72–e227. doi: 10.1161/CIR.0000000000000923.
3. Vahanian A, Beyersdorf F, Praz F, et al. 2021 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heat J. 2022; 43: 561632. doi 10.1093/eurheartj/ehab395.
4. Tribouilloy C, Rusinaru D, Grigioni F, et al. Indexing left ventricular end-systolic dimension to body size: Association with mortality in patients with degenerative mitral regurgitation. Eur J Heart Fail. 2024; 26(12): 2563-2569. doi: 10.1002/ejhf.3393.
5. Vaykin VE, Ryazanov MV, Zhiltsov DD, et.al. Modified mitral valve repair with its insufficiency of ischemic genesis. Sovremennye tehnologii v medicine. 2021; 13(2): 59-67 (In Russ.) doi: 10.17691/ stm2021.13.2.07.
6. Ling LH, Enriquez-Sarano M. Long-term outcomes of patients with flail mitral valve leaflets. Coron Artery Dis. 2000; 11(1): 3-9. doi: 10.1097/ 00019501-200002000-00002.
7. Imaev TE, Komlev AE, Kuchin IV, et al. Transcatheter mitral valve surgery using the edge-to-edge method in patients with severe mitral regurgitation (results of the MITRACLIP RUSSIA study). Russian Journal of Cardiology. 2022; 27(2): 83-91. (In Russ.)
8. Martyanova YB, Chernyshova EN, Kondratyev DA, Lyalyukova EA Asymptomatic severe mitral insufficiency with the background of undifferentiated connective tissue dysplasia syndrome. Clinical case of timely diagnosis and successful treatment. International Journal of Heart and Vascular Diseases. 2022; 10(36): 50-56. (In Russ.) doi: 10.24412/ 2311-1623-2022-36-50-56.
9. Nalyotov AV, Chalaya LF, Moskaljuk ON, et al. Mitral valve prolapse: current state of the problem. Bulletin of emergency and reconstructive surgery. 2020; 5(4): 80. (In Russ.)
10. Zhuravleva AS, Alexandrova MR, Bychkova LV, et al. Severe Mitral Regurgitation in a Patient with Myxomatous Mitral Valve Degeneration and Partial Detachment of the Chord of its Posterior Cusp. 2020; 4. (In Russ.) doi: 10.24411/2074-1995-2020-10027.
11. Deng M, Elmistekawy E, Mesana T, Chan V.Ann. Correction of Bileaflet Mitral Valve Prolapse Through Reduction of Posterior Leaflet Height. Thorac Surg. 2021; 111(1): e55-e56. doi: 10.1016/j.athoracsur.2020.04.131.
12. Aluru JS, Barsouk A, Saginala K, et al. Valvular Heart Disease Epidemiology. Med Sci (Basel). 2022; 10(2): 32. doi: 10.3390/medsci10020032.
13. Peters AS, Duggan JP, Trachiotis GD, Antevil JL. Epidemiology of Valvular Heart Disease. Surg Clin North Am. 2022; 102(3): 517-528. doi: 10.1016/j.suc.2022.01.008.
14. El Sabbagh A, Reddy YNV, Nishimura RA. Mitral Valve Regurgitation in the Contemporary Era: Insights Into Diagnosis, Management, and Future Directions. JACC Cardiovasc Imaging. 2018; 11(4): 628-643. doi: 10.1016/j.jcmg.2018.01.009.
15. Honda Y, Watanabe N, Nishino S, Shibata Y. Dynamic changes in the three-dimensional mitral complex geometry in a case of takotsubo cardiomyopathy with transient systolic anterior movement of the mitral valve. J Cardiol Cases. 2022; 26(3): 190-193. doi: 10.1016/j.jccase.2022.04.017.
16. Monteagudo RJM, Galderisi M, Buonauro A, Badano L, et al. Overview of mitral regurgitation in Europe: results from the European Registry of mitral regurgitation (EuMiClip). Eur Heart J Cardiovasc Imaging. 2018; 19: 503-7. doi: 10.1093/ehjci/jey011.
17. Huang AL, Dal-Bianco JP, Levine RA, Hung JW. Secondary mitral regurgitation: cardiac remodeling, diagnosis, and management. Struct Heart 2022; 7: 100-129. doi: 10.1016/j.shj.2022.100129.
18. Chan V, Chen SY, Mesana TG, et al. Randomized, controlled trial comparing mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis: the CAMRA CardioLink-2 study. Circulation. 2020; 142(14): 1342-1350. doi:10.1161/CIRCULATIONAHA.120.045272.16.
19. Nisivaco S, McCarthy PM, Kruse J, et al. Late results of chord transfer and other techniques for anterior leaflet repair without neochords. J Thorac Cardiovasc Surg. 2023: S0022-5223(23)00606-2. doi: 10.1016/j.jtcvs. 2023.05.047.
20. Lin X, Chen L, Zhang D, et al. Prediction of Surgical Approach in Mitral Valve Disease by XGBoost Algorithm Based on Echocardiographic Features. J Clin Med. 2023; 12(3): 1193. doi: 10.3390/jcm12031193.


