DOI: 10.25881/20728255_2023_19_1_56


Asanov O.N.1, Zaytsev A.E.1, Vakhaev D.S.2

1 The branch of the «Military Medical Academy named after S.M. Kirov», Moscow

2 Pirogov National Medical and Surgical Center, Moscow


Background: Despite the many existing methods of local impact on wounds, the search for new means of stimulating healing remains relevant. Certain prospects are associated with the use of a high-intensity erbium (Er:YAG) laser capable of not only sanitizing the wound surface, but also influencing the regeneration processes.

Aim: To evaluate the wound healing properties of a high-intensity Er:YAG laser in the treatment of patients with long-term non-healing wounds and when exposed to a complicated wound process in an experiment.

Materials and methods: In this work, the effect of erbium laser treatment of long-term non-healing wounds in patients with diabetes mellitus, venous and arterial insufficiency, as well as experimental wounds in rats was evaluated. During the study, visual changes in wound defects were analyzed in dynamics, planimetry was performed, bacteriological, cytological studies were performed, as well as morphological analysis using light and electron microscopy.

Results: The use of the Er:YAG laser in two modes accelerated the purification and epithelialization of wound defects. The regeneration stimulation regime promoted the growth of granulation tissue, and the cytological picture confirmed signs of active healing. Bacterial growth was absent in most wounds by the end of the observation period. According to morphological analysis, Er:YAG laser radiation increased the functional activity of fibroblasts, as well as stimulated collagen synthesis and angiogenesis.

Conclusions: The results of the clinical and experimental study confirm the wound healing properties of the Er:YAG laser. The radiation parameters and the possibility of laser operation in a stimulating mode can improve the results of wound treatment of various origins.

Keywords: erbium laser, long-term non-healing wounds, trophic ulcers, wound process, regeneration.


1. Hajhosseini B, Chiou GJ, Dori G, Fukaya E, Chandra V, Meyer S, Gurtner GC. Er:YAG laser vs. sharp debridement in management of chronic wounds: Effects on pain and bacterial load. Wound Repair Regen. 2020; 28(1): 118-125. doi: 10.1111/wrr.12764.

2. Alcolea JM, Hernández E, Martínez-Carpio PA, Vélez M, Khomchenko V, Sola A, Trelles MA. Treatment of Chronic Lower Extremity Ulcers with A New Er:Yag Laser Technology. Laser Ther. 2017; 26(3): 211-222. doi: 10.5978/islsm.17-OR-17.

3. Pikirenja II, Homenko VV. High-intensity lasers in medicine. Minsk: BelMAPO, 2017. (In Russ.)

4. Johnson MJ, Crisologo PA, Truong DH, Wukich DK, Oz OK, La Fontaine J, Lavery LA. Erbium: Yttrium Aluminum Garnet Laser Accelerates Healing in Indolent Diabetic Foot Ulcers. J Foot Ankle Surg. 2019; 58(6): 1077-1080. doi: 10.1053/j.jfas.2019.07.023.

5. Zaitsev AE, Asanov ON. Prospects for the use of a high-intensity erbium laser for the treatment of chronic wound process. Bulletin of Pirogov National Medical & Surgical Center. 2021; 16(2): 128-131. (In Russ.) doi: 10.25881/20728255_2021_16_2_128.

6. Patent RUS №2753955. Zajcev AE, Asanov ON, Mjasnikov NI. A method for modeling trophic purulent wounds in an experiment. (In Russ.)

7. Zaitsev AE, Asanov ON, Chekmareva IA. Analysis of the effectiveness of the erbium laser in the treatment of trophic purulent wounds in an experiment. Medical News of North Caucasus. 2023; 18(4): 394-397. (In Russ.) doi: 10.14300/mnnc.2023.18093.

8. Botsali A, Caliskan E, Tunca M. The Beneficial Effects of Erbium:Yttrium-Aluminum-Garnet Laser in an Ulcer Caused by Lower Leg Arteriopathy. J Am Podiatr Med Assoc. 2021; 111(6). doi: 10.7547/20-099.

9. Chilgar RM, Andurkar SP. Spatially modulated erbium YAG laser as a treatment for diabetic ulcer. J Wound Care. 2023; 32(10a): S21-S29. doi: 10.12968/jowc.2023.32.Sup10a.S21.

For citation

Asanov O.N., Zaytsev A.E., Vakhaev D.S. Bout the wound healing properties of the er:yag laser. Bulletin of Pirogov National Medical & Surgical Center. 2024;19(1):56-59. (In Russ.)