Authors
Rybachkov V.V.1, Khokhlov A.L.1, Shulgina M.A.1, Bereznyak N.V.1, Tsareva I.N.1, Baranov G.A.2, Zavyalov D.V.1, Chervyakov Yu.V.1
1 Yaroslavl State Medical University, Yaroslavl
2 Moscow State University of medicine, Moscow
Abstract
Backgraund: the clinical significance of the genetic predisposition to pancreatic necrosis is rather uncertain and requires further study.
Aims: to study the clinical significance of polymorphisms of the ADH1B, CYP2C19 (CYP2C19*2, CYP2C19*3) genes in the blood in acute destructive pancreatitis.
Materials and methods: genetic polymorphism testing of the genes ADH1B, CYP2C19*2, CYP2C19*3 was performed in 72 Russian patients with pancreatic necrosis. All patients were admitted to the surgical hospital in an emergency. The diagnosis of destructive pancreatitis was made on the basis of clinical and ultrasound monitoring, laparoscopy data (14 patients — 19.4%), and was also confirmed during surgical intervention. Surgical aid was reduced to puncture and drainage sanitation of fluid formations in 36 patients (50%). The genetic study was conducted in the period from 2020 to 2022 inclusive in patients undergoing treatment in a surgical hospital.
Results: in the study group, polymorphisms of the ADH1B gene occurred with a frequency of 34.7%. Polymorphisms of the CYP2C19 gene were detected in 37.5% of cases. Polymorphisms of the CYP2C19*3 phenotype were not detected in all groups.
Conclusions: it was found that an increase in the frequency of mutation of the ADH1B gene is associated with the formation of pancreatic abscess and purulent-necrotic pancreatitis, and the CYP2C19 gene is predominantly only pancreatic abscess.
Keywords: рancreatic necrosis, clinical course, genetic polymorphism, ADH1B, CYP2C19.
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