Исследования первых антиагрегантов: ацетилсалициловая кислота, тиклопидин и клопидогрел

Гительзон Д.Г. ¹, Файбушевич А.Г.², Гительзон Е.А.², Денека А.Я.³, Васильев А.Э.¹, Данишян К.И.¹

Антиагреганты значительно снизили смертность и заболеваемость ИБС, нарушениями мозгового кровообращения, артериальной недостаточностью нижних конечностей. Поэтому антиагреганты являются важной частью оптимальной медикаментозной терапии у таких пациентов. Ацетилсалициловая кислота остается наиболее часто рекомендованным лекарственным препаратом, особенно для профилактики тромботических осложнений. Клопидогрел является альтернативой ацетилсалициловой кислоте, а также важным компонентом двойной антитромботической терапии при баллонной ангиопластике и стентировании. Тиклопидин не используется в практике согласно клиническим рекомендациям из-за многочисленных побочных эффектов и разработки более безопасных и эффективных антагонистов P2Y12 рецепторов.

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