DOI: 10.25881/20728255_2021_16_2_110


Druzhinina N.А., Sapelkin S.V.

National medical state center of surgery named after A.V. Vishnevsky, Moscow


The article provides a literature review of publications highlighting current trends in the treatment of patients with venous angiodysplasia. The main method of treatment for angiodysplasias is resection. However, they carry risks of postoperative complications such as bleeding and nerve damage. In this review, special attention is paid to minimally invasive techniques (sclerobliteration, laser and radiofrequency obliteration), which can compete with open interventions. Based on the data of non-invasive examination methods, in compliance with the principles of minimally invasiveness, it is possible to obtain a sufficient therapeutic result to eliminate the main clinical manifestations of the disease.

Keywords: angiodisplasya, laser ablation, radiofrequency ablation, scleroterapy.


1. Virchow R. Krankhaften Geschwulste. Hirschwald, Berlin, 1863; 443. (In German).

2. Harvey W. The anatomical lectures of William Harvey. Royal College of Physicians, London; 1964.

3. von Pitha F. Die Krankheiten der Extremitäten. In: Von Pitha F, Billroth T, editors. Handbuch der allgemeinen und speciellen Chirurgie, mit Einschluss der topographischen Anatomie und Verbandlehre. Erlangen, 1869. (In German).

4. Malan E., Puglionisi A. Congenital angiodysplasias of extermities (Note II: Arterial, arterial and venous and hemolymphatic dysplasias). The Journal of cardiovascular surgery. 1965; 6: 255-345.

5. Fairbairn GF, Juergens JL, Spittel JA. Peripheral vascular diseases. Arteriovenous fistulas. Saunders, Philadelphia, 1972

6. Geoffroy SH. Histoire générale et particulière des anomalies de l´organisation ches l´homme et les animaux. Bailliere, Paris; 1832. (In French).

7. Trelat U, Monod A. De l’hypertrophie unilatérale ou totale du corps. Arch Gen de Med. 1869; 13: 536-558. (In French).

8. Klippel M, Trenaunay I. Du noevus variqueux et ostéohypertrophique. Arch Gen Med. 1900; 3:641-672. (In French).

9. Weber FP. Angioma formation in connection with hypertrophy of limbs and hemihypertrophy. The British journal of dermatology. 1907; 19: 231-235.

10. Sicard JA, Forestier G. Injections intravasculaires d’huile iodeé sous control radiologique. CR Soc Biol. 1923; 88: 1200-1202.

11. de Takats G. Vascular anomalies of the extremities. Report of five cases. Surgery Gynecological Obstet. 1932; 55: 227.

12. Pratt GH. Arterial varices. A syndrome. Am J Surgery. 1949; 77(4): 456-460. doi: 10.1016/0002-9610(49)90398-0.

13. Servelle M, Trinquecoste D. Des angiomes veineux. Arch Mal Coeur. 1948; 41: 436. (In French).

14. Olivier CL. Maladies des veins. 1957; Masson, Paris. (In French).

15. Malan E, Puglionisi A. Congenital angiodysplasias of the extremities (note I: generalities and classification; venous dysplasias). J Cardiovascular Surgery. 1964; 5: 87–130.

16. Krakovsky NI, Taranovich VA. Hemangiomas (diagnosis and treatment). Moscow: Medicine; 1974. (In Russ).

17. Krakovsky NI, Taranovich VA. New in the diagnosis and surgical treatment of extensive hemangiomas of the extremities. Experimental surgery and anesthesiology. 1964; (4): 62-67. (In Russ).

18. Dan VN, et al. Angiodysplasia (congenital vascular malformations). Moscow: Verdana. 2008; 200 р. (In Russ).

19. Isakov YuF, Tikhonov YuA. Congenital malformations of peripheral vessels in children. Moscow: Medicine; 1974. 116 р. (In Russ).

20. Dan V.N. Diagnostics and surgical treatment of congenital angiodysplasias. [Abstract dissertation] Moscow; 1989. (In Russ).

21. Sapelkin SV. Optimization of diagnostic and therapeutic tactics in patients with angiodysplasia. [Abstract dissertation], Moscow; 2009. (In Russ).

22. Shalimov AA, Dryuk NF, Polishchuk YuE et al. Diagnostics and surgical treatment of arteriovenous angiodysplasias of peripheral vessels. Clinical surgery. 1982; 7: 5-10. (In Russ).

23. Strandness Jr DE. Ultrasonic flow detection: A useful technic in the evaluation of peripheral vascular disease. The American Journal of Surgery. 1967; 113(3): 311-320. doi: 10.1016/0002-9610(67)90272-3.

24. Lee B, Mattassi R et al. Consensus on controversial issues in contemporary diagnosis and management of congenital vascular malformation: Seoul communication. Int J Angiology. 2005; 13: 182-192.

25. Shubin AA. The role of computed tomography in the choice of tactics for surgical treatment of angiodysplasias. [Abstract dissertation], Moscow; 1996. (In Russ).

26. Galaktionova LA. The role of magnetic resonance imaging in determining the tactics of surgical treatment of patients with angiodysplasia. [Abstract dissertation], Moscow, 2007. (In Russ).

27. Creasey JL. Gadolinium-enhanced MR angiography. Radiology. 1990; 175: 280-283. doi: 10.1148/radiology.175.1.2315497.

28. Hasuo K. Contrast-enhanced MRI in spinal arteriovenous malformations and fistulae before and after embolisation therapy. Neuroradiology. 1996; 38: 609-614. doi: 10.1007/s002340050318.

29. Enjolras O, Mulliken JB. Vascular cutaneous anomalies in children: malformation and hemangiomas. Pediatr. Surg. Int. 1996; 11: 290. doi: 10.1007/BF00497795.

30. Mulliken J. Vascular birthmarks: hemangiomas and malformations. WB Saunders, Philadelphia. 1988.

31. Holdin SA. Hemangiomas and their treatment. Leningrad: Medicine, 1935. (In Russ).

32. Cabrera J, García-Olmedo MA., Redondo P. Treatment of venous malformations with sclerosant in microfoam form. Archives of dermatology. 2003; 139(11): 1409-1416. doi: 0.1001/archderm.139.11.1409.

33. Orlando JL, et al. Escleroterapia com etanol em malformações venosas da cabeça e pescoço. Einstein São Paulo. 2014; 12(2): 181-186. (In Brasil). doi: 10.1590/s1679-45082014ao2844.

34. Steiner F, FitzJohn T. Ethanol sclerotherapy for venous malformation. ANZ journal of surgery. 2016; 86(10): 790-795. doi: 10.1111/ans.12833.

35. Teusch VI. Ethanol-gel sclerotherapy of venous malformations: effectiveness and safety. American Journal of Roentgenology. 2017; 209(6): 1390-1395. doi: 10.2214/AJR.16.17603.

36. Li HB. Clinical efficacy of absolute ethanol combined with n‑butyl cyanoacrylate sclerotherapy in the treatment of Puig's classified advanced venous malformation in children. Experimental and therapeutic medicine. 2019; 17(2): 1276-1281. doi: 10.3892/etm.2018.7051.

37. Berenguer Â. Sclerotherapy of craniofacial venous malformations: complications and results. Plastic and Reconstructive Surgery. 1999; 104: 1-11.

38. Goyal M. Venous vascular malformations in pediatric patients: comparison of results of alcohol sclerotherapy with proposed MR imaging classification. Radiology. 2002; 223: 639-644. doi: 10.1148/radiol.2233010025.

39. Burrows PE. Percutaneous Treatment of Low Flow Vascular Malformations. Journal of Vascular and Interventional Radiology. 2004; 15: 431-445. doi: 10.1097/

40. Wiedman A. Die Verodungsbehandlung der Kkavernosen Hamangiome. Hautarzt. 1965; 16: 294-298. (In German).

41. Cabrera J. Treatment of venous malformations with sclerosant in microfoam form. Archives of dermatology. 2003; 139(11): 1409-1416. doi: 10.1001/archderm.139.11.1409.

42. Golovyuk AL. Percutaneous laser coagulation in the treatment of patients with venous angiomatosis [dissertation]. Moscow, 2008. (In Russ)

43. Bertolotti M. The history of the laser. Laser treatment of facial venous vascular malformations. Ann Plast Surg. 1997; 38: 371-378. doi: 10.1097/00000637-199704000-00011.

44. Huegel U. Implementation of new endovenous treatments in therapy for lateral embryonic veins. Journal of vascular surgery cases and innovative techniques. 2019; 5(3): 243-247. doi: 10.1016/j.jvscit.2018.12.016.

45. Limongelli L. Diode Laser Photocoagulation of Intraoral and Perioral Venous Malformations After Tridimensional Staging by High Definition Ultrasonography. Photobiomodulation, Photomedicine, and Laser Surgery. 2019; 37(11): 722-728. doi: 10.1089/photob.2019.4635.

46. Khramov YuA. D'Arsonval Jacques Arsene. Physics: Biographical reference book. A.I. Akhiezer, editor. Ed. 2nd, rev. and add. Moscow: Nauka, 1983: 98. (In Russ).

47. Pollack SV. The history of electrosurgery. Dermatologic Surgery. 2000; 26(10): 904-908. doi: 10.1046/j.1524-4725.2000.026010904.x.

48. van der Linden E, et all. Radiofrequency ablation for treatment of symptomatic low-flow vascular malformations after previous unsuccessful therapy. J Vasc Interv Radiol. 2005; 16(5): 747-50. doi: 10.1097/01.RVI.0000157245.60426.7B.

49. Kim AH, et al. Percutaneous radiofrequency ablation: A novel treatment of facial venous malformation. Journal of vascular surgery. 2009; 50(2): 424-427. doi:10.1016/j.jvs.2009.03.047.

50. Gao Y et al. Management of venous malformations with percutaneous radiofre-quency thermal ablation. British Journal of Dermatology. 2012; 167(3): 637-642. doi: 10.1111/j.1365-2133.2012.10963.x.

51. Behravesh S, et al. Venous malformations: clinical diagnosis and treatment. Cardiovascular diagnosis and therapy. 2016; 6(6): 557. doi: 10.21037/cdt.2016.11.10.

For citation

Druzhinina N.А., Sapelkin S.V. Venous angiodysplasias — the current state of the problem (literature review). Bulletin of Pirogov National Medical & Surgical Center. 2021;16(2):110-115. (In Russ.)