Authors
Kurbanov B.B.1, Kurbanov D.D.1, Ibragimov Z.Z.2
1 Tashkent Pediatric Medical Institute, Tashkent
2 Republican Specialized Scientific and Practical Medical Center of Hematology, Tashkent
Abstract
Background. One of the genetic risk factors for the development of preeclampsia may be polymorphism of the ESR1 gene.
The aim of the study was to study the polymorphism of the ESR1 gene in women with preeclampsia.
Research methods. We used a DNA samples of patients with clinically diagnosed preeclampsia. Isolation of DNA from blood and PCR analysis were performed by test systems from Ampli Prime Ribot-prep (“Next Bio”, Russia).
Results. Comparison of the frequencies of genotypes and alleles of the ESR1 gene polymorphism in the both studied groups did not reveal statistically significant differences. In the main group, the frequency of the G allele of polymorphism of the ESR1 gene was 88.3%, in the control group - 85.7%, which indicated an association with an increased risk of preeclampsia.
Conclusion. The presence of the G allele and the hetero- and homozygous G/A and GG genotypes increases, and the identification of the A allele and the AA genotype decreases the risk of developing preeclampsia.
Keywords: preeclampsia, polymorphism, ESR1, genotype G / A and GG, PCR analysis.
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