DOI: 10.25881/BPNMSC.2020.91.54.017

Authors

Levchuk A.L., Sysoev O.Yu., Stoiko Yu.M.

Pirogov National Medical and Surgical Center, Moscow

Abstract

The introduction of modern techniques of surgical techniques in hernioplasty and use of mesh endoprostheses, is often accompanied by the risk of infectious complications.This paper presents a review of the available literature, describing the use of the negative pressure wound therapy on treatment of patients with infected mesh implants after hernioplasty.

Infection of the implant is accompanied by the formation of biofilms, while antibacterial therapy does not allow achieving adequate efficacy in the treatment of the infected surface. The use of negative pressure wound therapy in patients with infected endoprostheses prevents the formation of biofilms, reduces the bacterial load on the wound, making it possible to salvage the installed implant and avoid repeated surgical interventions.

Keywords: negative pressure wound therapy (NPWT), mesh-site infection, hernia repair, biofilm.

References

1. Obolenskiy VN, Enokhov VYu, Kharitonov SV. Clinical efficacy of local negative pressure method for treatment of infectious wound complications after non-stretching hernioplasty. Medical alphabet. 2018; 1(9): 45–49. (In Russ).

2. Buzoleva LS, Puz AV, Sinebryukhov SL, et al. The implant — related infections, associated with the problem of biofilm formation. Modern Problems of Science and Education.2016; (1): 42. (In Russ).

3. Höer J, Lawong G, Klinge U, Schumpelick V. Einflussfaktoren der Narbenhernienentstehung. Retrospektive Untersuchung an 2.983 laparotomierten Patienten über einen Zeitraum von 10 Jahren [Factors influencing the development of incisional hernia. A retrospective study of 2,983 laparotomy patients over a period of 10 years]. Chirurg. 2002 May; 73(5): 474–80. doi: 10.1007/s00104-002-0425-5.

4. Ponomareva YV, Belokonev VI, Volova LT. The morphological basis of the causes of recurrence in patients with postoperative ventral hernias. Fundamental’nye issledovanija. 2013; 9(2): 63–266. (In Russ).

5. George CD, Ellis H. The results of incisional hernia repair: a twelve year review. Ann R Coll Surg Engl. 1986; 68: 185–187.

6. Dietz UA, Spor L, Germer CT. Therapie der Netz(-Implantat)-Infektion [Management of mesh-related infections]. Chirurg. 2011 Mar; 82(3): 208–17. doi: 10.1007/s00104-010-2013-4

7. Plymale MA, Davenport DL, Walsh-Blackmore S, et al. Costs and Complications Associated with Infected Mesh for Ventral Hernia Repair. Surg Infect (Larchmt). 2020 May; 21(4): 344–349. doi: 10.1089/sur.2019.183.

8. Janssen AH, Mommers EH, Notter J, et al. Negative pressure wound therapy versus standard wound care on quality of life: a systematic review. J Wound Care. 2016 Mar; 25(3): 154, 156–159. doi: 10.12968/jowc.2016.25.3.154.

9. Petro CC, Novitsky YW. Classification of Hernias. In: Novitsky Y. (eds) Hernia Surgery. Springer, Cham. URL.

10. Pérez-Köhler B, Bayon Y, Bellón JM. Mesh Infection and Hernia Repair: A Review. Surg Infect (Larchmt). 2016 Apr; 17(2): 124–37. doi: 10.1089/sur.2015.078.

11. Ćirković I, Jocić D, Božić DD, et al. The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. Adv Skin Wound Care. 2018 Aug; 31(8): 361–364. doi: 10.1097/01.ASW.0000540070.07040.70.

12. Chernjavsky VI. Bacterial biofilms and infection (lecture). Ann Mechnikov Institute. 2013; (1): 86–90. (In Russ).

13. Reśliński A, Dąbrowiecki S, Głowacka K. The impact of diclofenac and ibuprofen on biofilm formation on the surface of polypropylene mesh. Hernia. 2015 Apr; 19(2): 179–85. doi: 10.1007/s10029-013-1200-x.

14. Sharma R, Fadaee N, Zarrinkhoo E, et al. Why we remove mesh. Hernia 22, 953–959 (2018). URL.

15. Kalish YI, Ametov LZ, Shayusupov AR. Chronic paraprosthesis infection after allohernioplasty. Klinichna medycyna. 2016; 21(4): 62–66. (In Russ).

16. Cherepanin A.I., Povetkin A.P., Lucevich O.Je. Atlas oslozhnenij hirurgii gryzh perednej brjushnoj stenki. Moscow: GJeOTAR-Media; 2017. p. 208–210. (In Russ).

17. Yang H, Xiong Y, Chen J, Shen Y. Study of mesh infection management following inguinal hernioplasty with an analysis of risk factors: a 10-year experience. Hernia. 2020 Apr; 24(2): 301–305. doi: 10.1007/s10029-019-01986-w.

18. Kao AM, Arnold MR, Augenstein VA, Heniford BT. Prevention and Treatment Strategies for Mesh Infection in Abdominal Wall Reconstruction. Plast Reconstr Surg. 2018 Sep; 142(3): 149S–155S. doi: 10.1097/PRS.0000000000004871.

19. Baharestani MM, Gabriel A. Use of negative pressure wound therapy in the management of infected abdominal wounds containing mesh: an analysis of outcomes. International Wound Journal. 2011; 8: 118–125. doi:10.1111/j.1742-481X.2010.00756.x.

20. Nobaek S, Rogmark P, Petersson U. Negative Pressure Wound Therapy for Treatment of Mesh Infection After Abdominal Surgery: Long-Term Results and Patient-Reported Outcome. Scand J Surg. 2017 Dec; 106(4): 285–293. doi: 10.1177/1457496917690966.

21. Parshikov VV. Inflammatory complications of the abdominal wall prosthetic repair: diagnostics, treatment, and prevention (review). Sovremennye tehnologii v medicine 2019; 11(3): 158–178. (In Russ). doi: 10.17691/stm2019.11.3.19.

22. Sonis AG, Grachev BD, Stolyarov EA, Ishutov IV. Prevention And Treatment Of Infection Wound Complications At Prosthetic Hernia Repair. Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2014; 1(2): 16–23. (In Russ). doi: 10.17650/2408-9613-2014-1-2-16-23.

23. Deleyto E, García-Ruano A, González-López JR. Negative pressure wound therapy with instillation, a cost-effective treatment for abdominal mesh exposure. Hernia. 2018 Apr; 22(2): 311–318. doi: 10.1007/s10029-017-1691-y.

24. Ovdenko AG, Nefedov ON. Vacuum treatment: from the Roman Empire to the present day. Zdorov’e — osnova chelovecheskogo potenciala: problemy i puti ih reshenija. 2018; 13(3): 1159–1178. (In Russ).

25. Davydov Ju A., Larichev A B. Vakuum-terapija ran i ranevoj process. Moscow: Medicina. 1999. p.48–108. (In Russ).

26. Davydov JuA., Usenko MJa., Larichev AB. Vakuum-terapija kak aktivnyj metod lechenija ostryh gnojnyh zabolevanij mjagkih tkanej i gnojnyh ran. Hirurgija. 1987; (3): 153–154. (In Russ).

27. Fleischmann W, Strecker W, Bombelli M, Kinzl L. Vacuum sealing as treatment of soft tissue damage in open fractures. Der Unfallchirurg. 1993 Sep; 96(9): 488–492.

28. Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assist ed closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997 Jun; 38(6): 553–62. doi: 10.1097/00000637-199706000-00001.

29. Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014 Jul; 51(7): 301–31. doi: 10.1067/j.cpsurg.2014.04.001.

30. Chasnoits ACh, Zhilinski EV, Serabrakou AE, Leshchanka VT. Action mechanisms of negative pressure wound treatment. Meditsinskie novosti. 2015; (7): 12–16. (In Russ).

31. Hasan MY, Teo R, Nather A. Negative-pressure wound therapy for management of diabetic foot wounds: a review of the mechanism of action, clinical applications, and recent developments. Diabet Foot Ankle. 2015 Jul 1; 6: 27618. doi: 10.3402/dfa.v6.27618.

32. Cherkasov MF, Galashokyan KM, Startsev YM, Cherkasov DM. The use of vacuum therapy in treatment of the pilonidal sinus disease (a review of the literature). Modern Problems of Science and Education. Surgery. 2015; (5): 58–62. (In Russ).

33. Borys S, Hohendorff J, Frankfurter C, et al. Negative pressure wound therapy use in diabetic foot syndrome-from mechanisms of action to clinical practice. Eur J Clin Invest. 2019 Apr; 49(4): 13067. doi: 10.1111/eci.13067.

34. Kirkby K, Wheeler J, Farese J, et al. Surgical views: Vacuum-assisted wound closure: application and mechanism of action. Compend Contin Educ Vet. 2009 Dec; 31(12): E1-5, E7; quiz E6.

35. Zeybek B, Li S, Fernandez JW, et al. Computational modelling of wounded tissue subject to negative pressure wound therapy following trans-femoral amputation. Biomech Model Mechanobiol. 2017 Dec; 16(6): 1819–1832. doi: 10.1007/s10237-017-0921-7.

36. Lalezari S, Lee CJ, Borovikova AA, et al. Deconstructing negative pressure wound therapy. Int Wound J. 2017 Aug; 14(4): 649–657. doi: 10.1111/iwj.12658.

37. Guoqi W, Zhirui L, Song W, et al. Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model. Antonie Van Leeuwenhoek. 2018 Sep; 111(9): 1557–1570. doi: 10.1007/s10482-018-1045-5.

38. Bradley BH, Cunningham M. Biofilms in chronic wounds and the potential role of negative pressure wound therapy: an integrative review. J Wound Ostomy Continence Nurs. 2013 Mar-Apr; 40(2): 143–9. doi: 10.1097/WON.0b013e31827e8481.

39. Li T, Wang G, Yin P, et al. Adaptive expression of biofilm regulators and adhesion factors of Staphylococcus aureus during acute wound infection under the treatment of negative pressure wound therapy in vivo. Exp Ther Med. 2020 Jul; 20(1): 512–520. doi: 10.3892/etm.2020.8679.

40. Gupta S, Gabriel A, Lantis J, Téot L. Clinical recommendations and practical guide for negative pressure wound therapy with instillation. Int Wound J. 2016 Apr; 13(2): 159–74. doi: 10.1111/iwj.12452.

41. Rock, R. (2014). Guidelines for Safe Negative-Pressure Wound Therapy: Rule of Thumb: Assess Twice, Dress Once. Wound Care Advisor; 3(2): 29–33.

42. Yadav S, Rawal G, Baxi M. Vacuum assisted closure technique: a short review. Pan Afr Med J. 2017 Nov 21; 28: 246. doi: 10.11604/pamj.2017.28.246.9606.

43. Stinner DJ, Waterman SM, Masini BD, Wenke JC. Silver dressings augment the ability of negative pressure wound therapy to reduce bacteria in a contaminated open fracture model. J Trauma. 2011 Jul; 71(1): 147–50. doi: 10.1097/TA.0b013e318221944a.

44. Kim PJ, Silverman R, Attinger CE, Griffin L. Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds. Cureus. 2020 Jul 7; 12(7): 9047. doi: 10.7759/cureus.9047.

45. Cherdantsev DV, Pervova OV, Shaderov IA, et al. Vacuum-assisted closure: a modernized method for treating patients with widespread purulent peritonitis. Experimental study. Modern Problems of Science and Education. Surgery. 2018; (6): 24–35. (In Russ).

46. Razmakhnin EV, Shangin VA, Kudryavtseva OG, Okhlopkov DY. Possibilities of vacuum-instillation therapy with dimexidum and betadine in the treatment of purulent wounds. Acta Biomedica Scientifica (East Siberian Biomedical Journal). 2017; 2(6): 153–156. (In Russ). doi: 10.12737/article_5a0a8e0d03dc42.56682733.

47. Scimeca CL, Bharara M, Fisher TK, et al. Novel use of insulin in continuous-instillation negative pressure wound therapy as «wound chemotherapy». J Diabetes Sci Technol. 2010 Jul 1; 4(4): 820–4. doi: 10.1177/193229681000400408.

48. Anghel EL, Kim PJ. Negative-Pressure Wound Therapy: A Comprehensive Review of the Evidence. Plast Reconstr Surg. 2016 Sep; 138(3): 129–37. doi: 10.1097/PRS.0000000000002645.

49. Berrevoet F, Vanlander A, Sainz-Barriga M, et al. Infected large pore meshes may be salvaged by topical negative pressure therapy. Hernia. 2013 Feb; 17(1): 67–73. doi: 10.1007/s10029-012-0969-3.

50. Karpov OE, Stojko YM, Levchuk AL, et al. Vakuumnaja aspiracionnaja terapija (NPWT) v lechenii gnojnyh ran posle gernioplastik s implantaciej setchatyh allotransplantatov bol’shih razmerov. Infekcii v hirurgii. 2018; 16(1–2): 74. (In Russ).

For citation

Levchuk A.L., Sysoev O.Yu., Stoiko Yu.M. Negative pressure wound therapy for treatment of mesh infection after hernia repair. Bulletin of Pirogov National Medical & Surgical Center. 2020;15(4):91-95. (In Russ.) https://doi.org/10.25881/BPNMSC.2020.91.54.017