DOI: DOI: 10.25881/BPNMSC.2020.61.59.026

Authors

Kuzmin D.B.2, Kokorin V.V.1, 2, Epifanov S.A.2, Krainyukov P.E.1, 3

1 Central Military Clinical Hospital. P.V. Mandryka of the Ministry of Defense of the Russian Federation, Moscow

2 Pirogov National Medical and Surgical Center, Moscow

3 Peoples Friendship University of Russia (RUDN University), Moscow

Abstract

Summary data of contemporary literature focuses on enthesopathies. The article describes the issues of etiopathogenesis, clinic, diagnosis, treatment and prevention. The area of enthesis becomes a “weak link” in the apparatus of the periarticular tissues, where under excessive load micro- and macroscopic lesions occur, which subsequently lead to inflammation. Inflammation of the enthesis enhances the degeneration of adjacent tissues of the tendons, ligaments, cartilage, bone. The causes of enthesopathy are congenital bone abnormalities, osteochondrosis leading to radicular syndrome (compression of the spinal nerves), microtrauma of ligaments and tendons, metabolic disorders (for example, with osteoporosis and gout), severe prolonged physical activity, various endocrine and infectious diseases, and also autoimmune and inflammatory joint damage. The question of the etiopathogenesis of the disease remains open, as a result of which there is no pathogenetically substantiated treatment. Despite the variety of medical devices and physiotherapeutic procedures, the treatment results remain unsatisfactory, there is a high percentage of relapses and a chronic process. Inflammatory and degenerative-dystrophic damage to the enthesis is attracting increasing attention, as it represents one of the peculiar groups of diseases of the bone-ligament-tendon complex and makes a significant contribution to the clinical picture and pathology.

Keywords: enthesis, bone-ligament-tendon complex, non-calcified fibrocartilage, etiopathogenesis.

References

1. Kirsanov VA, Bordukov GG, Polovinko VV. Analysis of the effectiveness of plasma therapy in the treatment of enthesopathies of the upper limb. In: Tekhnologicheskie innovatsii v travmatologii, ortopedii i neirokhirurgii: integratsiya nauki i praktiki. Saratov: Amirit; 2019. P. 116–119.

2. Amy SK, Maripat C, Michael H. New insights into pathogenesis, diagnostic modialities, and treatment. Enthesits. 2016;68(2):312–322.

3. Kirillova ER, Lapshina SA, Myasoutova LI, et al. Approaches to Objectification of Periarticular Tissue Damage. Revmatologiya. Nefrologiya. Travmatologiya. 2008;(25):11–14.

4. Orel AM. Mechanisms of damage to entheses in patients with ankylosing spondylitis. Manual therapy. 2013;(2):34–40.

5. Juneja SC, Veillette C. Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review. Arthritis. 2013;2013:154812. doi. 10.1155/2013/154812.

6. Wang X, Xie L, Crane J, et al. Aberrant TGF-β activation in bone tendon insertion induces enthesopathy — like disease. J Clin Invest. 2018;128(2):846–860.

7. Khitrov NA. Paraartikulyarnyye tkani: varianty porazheniya i ikh lecheniye. Russkii meditsinskii zhurnal. 2017;(3):177–187.

8. Sigidin YA, Lukina MN. Biologicheskaya terapiya v revmatologii. Prakticheskaya meditsina. 2015;(3):304.

9. Wes C. Enthesopathy — a personal perspective on its manifestations, implications and treatment. Australas J Ultrasound Med. 2010;13(4):19–23.

10. Gleb S, Itzhak R. Enthesis as a target organ in rheumatic diseases: an expanding frontier. Clin Rheumatol. 2017; 36(10):2163–2165.

11. Wilkinson HA. Injection therapy for enthesopathies causing axial spine pain and the “failed back syndrome”: a single blinded, randomized and cross-over study. Pain Physician. 2005;8(2):167–173.

12. Belen’kiy AG. Entezopatii pri seronegativnykh spondiloartritakh. Consilium medicum. 2006;8(2):11–14.

13. Dennis MG, Kay-Geert AH, Ai LT. Differentiation between osteoarthritis and psoriatic arthritis: implications for pathogenesis and treatment in the biologic therapy era. Rheumatology. 2015;54(1):29–38.

14. Benjamin M, McGonagle D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv Exp Med Biol. 2009;649:57–70. doi: 10.1007/978-1-4419-0298-6_4.

15. Benjamin M, McGonagle D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv Exp Med Biol. 2009;649:57–70. doi: 10.1007/978-1-4419-0298-6_4.

16. Benjamin M, McGonagle D. The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat. 2001;199(Pt 5):503–526. doi: 10.1046/j.1469-7580.2001.19950503.x.

17. Benjamin M, Toumi H, Ralphs JR, et al. Where tendons and ligaments meet bone: attachment sites (“enthuses”) in relation to exercise and/or mechanical load. J Anat. 2006;208:471–490.

18. Sudoł-Szopińska I, Kontny E, Zaniewicz-Kaniewska K, et al. Role of inflammatory factors and adipose tissue in pathogenesis of rheumatoid arthritis and osteoarthritis. Part I: Rheumatoid adipose tissue. J Ultrason. 2013;13(54):192–201. doi: 10.15557/JoU.2013.0032.

19. Sudoł-Szopińska I, Zaniewicz-Kaniewska K, Kwiatkowska B. Spectrum of ultrasound pathologies of Achilles tendon, plantar aponeurosis and flexor digiti brevis entheses in patients with clinically suspected enthesitis. Pol J Radiol. 2014;79:402–408. doi: 10.12659/PJR.890803. .

20. François RJ, Braun J, Khan MA. Entheses and enthesitis: a histopathologic review and relevance to spondyloarthritides. Curr Opin Rheumatol. 2001;13(4):255–264. doi: 10.1097/00002281-200107000-00003.

21. Hébert HL, Ali FR, Bowes J, et al. Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy. Br J Dermatol. 2012;166(3):474–482. doi: 10.1111/j.1365-2133.2011.10712.x.

22. O’Rielly DD, Rahman P. Advances in the genetics of spondyloarthritis and clinical implications. Curr Rheumatol Rep. 2013;15(8):347. doi: 10.1007/s11926-013-0347-x.

23. Goldring SR. Osteoimmunology and bone homeostasis: relevance to spondyloarthritis. Curr Rheumatol Rep. 2013;15(7):342. doi: 10.1007/s11926-013-0342-2.

24. Sudoł-Szopińska I, Kwiatkowska B, Maśliński W. Enthesopathies and enthesitis. Part 1. Etiopathogenesis. J Ultrason. 2015;15(60):72–84. doi: 10.15557/JoU.2015.0006.

25. Karateyev AY, Karateyev DY, Orlova YS, et al. «Malaya» revmatologiya: nesistemnaya revmaticheskaya patologiya okolosustavnykh myagkikh tkaney verkhney konechnosti. Chast’ 1. Sovremennaya revmatologiya. 2015;(9):4–15.

26. Abate M, Carlo L, Salini V, et al. Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. Clin Rheumatol. 2014;33(10):1517–1522. doi: 10.1007/s10067-014-2524-3.

27. Arend CF. Role of sonography and magnetic resonance imaging in detecting deltoideal acromialenthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain. J Ultrasound Med. 2014;33(4):557–561. doi: 10.7863/ultra.33.4.557.

28. Korolev SB, Nosov SB, Klenin AA. Novyi sposob operativnogo lecheniya pri entezopatiyakh plechevoy kosti. Voprosy rekonstruktivnoi i plasticheskoi khirurgii. 2012;15(3):57–60.

29. Adzhigaytkanova SK. Diagnostika i lecheniye otdel’nykh form revmaticheskikh zabolevaniy s pozitsii dokazatel’noy meditsiny. Uchebno-metodicheskoye posobie. Moscow; 2013. P. 6–23.

30. Gaynullina GR, Kirillova ER, Abdulganiyeva DI. Entezopatii pri vospalitel’nykh zabolevaniyakh kishechnika. Prakticheskaya meditsina. 2019;17(6–1):6–10.

31. Hitrov NA. Local injection therapy of periarticular tissue lesions. Khirurgia. 2017;(11):44–50.

32. Korolev SB, Kachesov AV, Nosov AA, et al. The method of surgical treatment of humeral epicondylitis. Travmatologiya i ortopediya Rossii. 2011;(4):114–117. doi: 10.21823/2311-2905-2011--4-114-117.

33. Godzenko AA. Lecheniye periartikulyarnykh bolevykh sindromov. RMZh. 2012;(7):382.

34. Shostak NA, Pravdyuk NG. Bone-muscular disorders in the practice of the internist - diagnostics, approaches to treatment. Practitioner. 2017;(12):68.

35. Arirachakaran A. Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis. J Orthop Traumatol. 2015;17(2):101–112. doi: 10.1007/s10195-015-0376-5.

36. Lee JK. The effect of plateletrich plasma on the differentiation of synovium derived mesenchymal stem cells. J Orthop. 2014;32(10):1317–1325. doi: 10.1002/jor.22668.

37. Lim W. Relationship of cytokine levels and clinical effect on plateletrich plasma treated lateral epicondylitis. J Orthop. 2018;36(3):913–920. doi: 10.1002/jor.23714.

38. Mishra AK. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med. 2014;42(2):463–471.

39. Scarpone M. Effectiveness of platelet-rich plasma injection for rotator cuff tendinopathy: a prospective open-label study. Glob Adv Health Med. 2013;2(2):26–31.

40. Sapin MR. Anatomiya cheloveka. Vol. 1. Moscow: Meditsina;1986. 288 p.

41. Jessica C, Elizabeth AO, Karl L, et al. Conventional therapy in adults with x-linked hypophosphatemia: effects on enthesopathy and dental disease. J Clin Endocrinol Metabol. 2015;100(10):3625–3632. doi: 10.1210/JC.2015-2199.

42. Shutov YuM, Shutova MZ, Novikov ND, et al. Optimal treatment for shoulder epicondylitis. Journal of Siberian Medical Sciences. 2015;(3):47.

43. Sirotko OV. Voprosy instrumental’noy diagnostiki reaktivnogo artrita. Vestnik VGMU. 2016;15(4):33–39.

44. Zubkov MA, Andreychenko AE, Kretov EI, et al. MR-tomografiya v sverkhvysokom pole: novyye zadachi i novyye vozmozhnosti. Moscow; 2018.

45. Iris E, Matthias B, Dennis GM, et al. MRI of enthesitis of the appendicular skeleton in spondyloarthritis. Ann Rheum Dis. 2007;66(12):1553–1559. doi: 10.1136/ard.2007.070243. 46. Gritsuk AA, Sereda AP. Akhillovo sukhozhilie. Moscow: RAEN; 2010. 313 p.

For citation

Kuzmin D.B, Kokorin V.V., Epifanov S.A., Krainyukov P.E. Role of infection in the etiopathogenesis of enthesopathies. Bulletin of Pirogov National Medical & Surgical Center. 2020;15(3-2):143-151. (In Russ.) https://doi.org/DOI: 10.25881/BPNMSC.2020.61.59.026