DOI: 10.25881/BPNMSC.2020.47.11.002


Askadinov M.N.1, Kadyraliev B.K.1, Kucherenko S.V.2, Musaev O.G.1, Arutyunyan V.B.1

1 The Federal Center for Cardiovascular Surgery named after S.G. Sukhanov, Ministry of Health of the Russian Federation

2 Perm State Medical University named after Academician E. A. Wagner, Ministry of Health of the Russian Federation


With degenerative defects of the aortic valve, a treatment method since the 1960s. is the excision of altered valves with implantation of a prosthetic valve. Most often, mechanical and biological prostheses are used, but each of them has problems with the need for lifelong anticoagulant therapy, thromboembolic and hemorrhagic complications, as well as negative indicators of mechanical valves compared to biological valves. Biological prostheses undergo degeneration quite quickly, especially in young patients, which leads to the need for reoperation. Despite the continuous change and modification of artificial valves, it can be concluded that an ideal aortic valve prosthesis has not yet been created.

Attempts have been made to replace some of the valves with various artificial and biological materials, but this, as a rule, is not widespread. In 2007 Shigeyuki Ozaki proposed a procedure for prosthetics of all aortic valve folds from the autopericardium treated with 0.6% glutaraldehyde solution [4]. Despite promising results, this Ozaki operation has not yet become widespread among cardiac surgeons. We will present you a literary review of the latest publications of the Ozaki operation for aortic valve disease.

Keywords: prosthesis, autologous pericardium, Ozaki.


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7. Ozaki S, Kawase I, Yamashita H, et al. Aortic valve reconstruction using autologous pericardium for aortic stenosis. Circ J. 2015;79(7):1504–1510. Doi: 10.1253/circj.CJ-14-1092.

8. Ozaki S, Kawase I, Yamashita H, et al. Midterm outcomes after aortic valve neocuspidization with glutaraldehyde-treated autologous pericardium. J. Thorac. Cardiovasc. Surg. 2018;155(6):2379–2387. Doi: 10.1016/j.jtcvs.2018.01.087.

9. Ozaki S. Ozaki Procedure: 1,100 patients with up to 12 years of follow-up. Turkish Journal of Thoracic and Cardiovascular Surgery. 2019;27(4):454. Doi: 10.5606/tgkdc.dergisi.2019.01904.

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For citation

Askadinov M.N., Kadyraliev B.K., Kucherenko S.V., Musaev O.G., Arutyunyan V.B. Prostheting of the valves of the aortal valve using the autopericard by processing with glutary aldehyde as an alternative approach to treating aortal valve stenosis. Bulletin of Pirogov National Medical & Surgical Center. 2020;3-2(15):10-14. (In Russ.)