DOI: 10.25881/BPNMSC.2020.17.22.020

Authors

Zhiburt E.B., Shestakov E.A., Kuznecov S.I.

Pirogov National Medical and Surgical Center, Moscow

Abstract

A review of the literature on hemolytic transfusion reactions is presented. A brief description of the epidemiology of this formidable complication of blood and blood component transfusion is given. The basic principles of prevention and treatment of various types of post-transfusion hemolysis are given in the context of a growing need for transplantation of allogeneic organs and tissues, increase in life expectancy of patients regularly receiving blood transfusion. The conclusion is drawn about the need for systematic training of doctors for adequate preventive, diagnostic and therapeutic actions when faced with a hemolytic transfusion reaction – an infrequent but serious adverse effect of transfusion therapy.

Keywords: blood, blood transfusion, hemolytic reaction, platelets, plasma, blood groups, immunohematology.

References

1. Zhiburt EB, Chemodanov IG. Problems of xenogenic transfusion. Hematology, transfusiology. Eastern Europe. 2018;4(4):539–541. (In Russ).

2. Zhiburt EB. Pirogov center blood service: yesterday, today, tomorrow. Bulletin of Pirogov National Medical & Surgical Center. 2006;1(1):55–57. (In Russ).

3. Zhiburt EB. Perelivanie krovi: istoriya i sovremennost’ (k 100-letiyu perelivaniya krovi v Rossii). Moscow: Pirogov National Medical & Surgical Center; 2019. (In Russ).

4. Shevchenko YuL, Zhiburt EB, Shestakov EA. Introduction of blood-saving ideology in the practice of the Pirogov center. Bulletin of Pirogov National Medical & Surgical Center. 2008;3(1):14–21. (In Russ).

5. Zhiburt EB, Shestakov EA, Karavaev AV, et al. Predposylka k posttransfuzionnomu oslozhneniyu. Bulletin of Pirogov National Medical & Surgical Center. 2010;5(1):84–88. (In Russ).

6. Shestakov EA, Sukhorukova II, Klyueva EA, Zhiburt EB. Wrong group blood in a donor container. Bulletin of Pirogov National Medical & Surgical Center. 2010;5(1):109–112. (In Russ).

7. Eihler OV, Chechetkin AV, Burdinskaya EA, et al. Rate and structure of complications occurring after transfusion of donor blood and its components in medical esteblishments of the Russian Federation in 2014-2017. Transfuziologiya. 2018;19(4):4–14. (In Russ).

8. fda.gov [Internet]. Transfusion/donation fatalities. Silver Spring, MD: Food and Drug Administration [cited 2019 Oct 31] Available from: https://www.fda.gov/vaccines-blood-biologics/report-problem-center-biologics-evaluation-research/transfusiondonation-fatalities.

9. Zhiburt EB, Shestakov EA, Likhonin DA, Karavaev AV. Women plasma transfusion injures recipient lungs. Bulletin of Pirogov National Medical & Surgical Center. 2011;6(2):109–111. (In Russ).

10. Zhiburt EB, Protopopova EB, Gubanova MN, et al. Transfusion-associated circulatory overload - “new” adverse effect of blood transfusion. Transfuziologiya. 2016;17(3):76–89. (In Russ).

11. Zhiburt EB, Madzaev SR, Chemodanov IG. Oslozhneniya donorstva i perelivaniya krovi. Moscow: Pirogov National Medical & Surgical Center; 2019. (In Russ).

12. Panch SR, Montemayor-Garcia C, Klein HG. Hemolytic transfusion reactions. N Engl J Med. 2019;381(2):150–162. doi: 10.1056/NEJMra1802338.

13. Zhiburt EB. Transfusiologiya. St. Petersburg: Piter; 2002. (In Russ).

14Zhiburt EB, Kuzmin NS, Vergopulo AA. Blood transfusion in solid organ transplantation. Transfuziologiya. 2015;16(4):12–23. (In Russ).

15. Chechetkin AV, Danilchenko VV, Grigoryan MSh, et al. Indicators of the blood service of the Russian Federation in 2018. Transfuziologiya. 2019;20(3):160–170. (In Russ).

16. Zarubin MV, Gubanova MN, Gaponova TV, et al. Efficiency and safety of platelet transfusions. Bulletin of Pirogov National Medical & Surgical Center. 2016;11(3):118–125. (In Russ).

17. Ayupova RF, Sultanbaev US, Yulbarisova AK, et al. Multicomponent collection of donor platelets for pooling. Transfuziologiya. 2017; 18(4):10–16. (In Russ).

18. Pietersz RN, Reesink HW, Panzer S, et al. Prophylactic platelet transfusions. Vox Sang. 2012;103(2):159–176. doi: 10.1111/j.1423-0410.2012.01595.x.

19. Tankaeva HS, Zhiburt EB. Blood transfusion for children with thalassemia. Vestnik Dagestanskoi gosudarstvennoi meditsinskoi akademii. 2018; (1):71–77. (In Russ).

20. Lee LE, Beeler BW, Graham BC, et al. Posttransfusion hyperhemolysis is arrested by targeting macrophage activation with novel use of Tocilizumab. Transfusion. 2020;60(1):30–35. doi: 10.1111/trf.15562.

21. Zhiburt EB, Shestakov EA, Sidorov SK. Formation of blood service in the Pirogov center. Bulletin of Pirogov National Medical & Surgical Center. 2017;12(4 Pt 1): 72–76. (In Russ).

22. Kozhemyako OV, Bakulina AYu, Zeiler EI, Zhiburt EB. Blood transfusion errors in emergency situation. Meditsina katastrof. 2017;(3):63–65. (In Russ).

23. Kozhemyako OV, Bakulina AYu, Zeiler EI, Zhiburt EB. Patsientu perelili inogruppnye eritrotsity. Kakie deistviya medpersonala priveli k oshibke? Zamestitel’ glavnogo vracha. 2017;(7):40–47. (In Russ).

24. Bruun MT, Yazer MH, Spinella PC, et al. Vox Sanguinis International Forum on paediatric indications for blood component transfusion. Vox Sang. 2019;114(5):523–530. doi: 10.1111/vox.12763.

25. Chemodanov IG, Shestakov EA, Kamelskikh DV, Zhiburt EB. Assessment of knowledge and skills of clinical ordinators in transfusiology. Bulletin of Pirogov National Medical & Surgical Center. 2018;13(1):124–126. (In Russ).

26. Zhiburt EB. Management patient’s blood at critical bleeding and massive transfusion. Bulletin of Pirogov National Medical & Surgical Center. 2013;8(4):71–77. (In Russ).

27. Zhiburt EB, Madzaev SR, Shestakov EA, et al. Medical and economical effectiveness of restrictive strategy for blood transfusion. Bulletin of Pirogov National Medical & Surgical Center. 2015;10(1):100–102. (In Russ).

28. Zhiburt EB, Chemodanov IG, Shestakov EA. Cryoprecipitate production in Russia: past, present and future. Russian journal of hematology and transfusiology. 2019;64(1):16–20. (In Russ). doi: 10.35754/0234-5730-2019-64-1-16-20.

29. Zhiburt EB, Shestakov EA. Hemopure - hemoglobin-based oxygen carrier. Bulletin of Pirogov National Medical & Surgical Center. 2012;7(2):70–77. (In Russ).

30. Wu B, Wu Y, Tang W. Heme catabolic pathway in inflammation and immune disorders. Front Pharmacol. 2019;10:825. doi: 10.3389/fphar.2019.00825.

31. Shokrgozar N, Tamaddon G. ABO Blood grouping mismatch in hematopoietic stem cell transplantation and clinical guides. Int J Hematol Oncol Stem Cell Res. 2018;12(4):322–328. doi: 10.18502/ijhoscr.v12i4.112.

32. Bathini S, Holtzman NG, Koka R, et al. Refractory postallogeneic stem cell transplant pure red cell aplasia in remission after treatment with daratumumab. Am J Hematol. 2019;94(8):E216–E219. doi: 10.1002/ajh.25515.

33. Shikhmirzaev TA, Chemodanov IG, Shestakov EA, et al. Pharmacoprophylaxis of transfusion reactions. Bulletin of Pirogov National Medical & Surgical Center. 2018; 13(2):95–99. (In Russ).

34. Win N, Almusawy M, Fitzgerald L, et al. Prevention of hemolytic transfusion reactions with intravenous immunoglobulin prophylaxis in U-patients with anti-U. Transfusion. 2019;59(6):1916–1920. doi: 10.1111/trf.15230.

35. Gubanova MN, Serba IK, Shestakov EA, et al. Blood transfusion evolution in the Pirogov center. Bulletin of Pirogov National Medical & Surgical Center. 2017;12(4 Pt 2):90–92. (In Russ).

36. Zhiburt EB, Karavaev AV, Glazov KN, Shestakov EA. Failure of primary determination of blood type by attending physician. Bulletin of Pirogov National Medical & Surgical Center. 2012;7(3):113–115. (In Russ).

37. Kozhemyako OV, Bakulina AYu, Zeiler EI, Zhiburt EB. Transfusion response in a far away hospital. Bulletin of Pirogov National Medical & Surgical Center. 2017;12 (4 Pt 2):147–149. (In Russ).

38. Mamadaliev DM, Farkhutdinov FF, Shestakov EA. et al. Preoperative risk factors for anemia and transfusion of red blood cells in cardiac surgery. Bulletin of Pirogov National Medical & Surgical Center. 2015;10(2):27–31. (In Russ).

39. De Vooght KM, Lozano M, Bueno JL, et al. Vox Sanguinis International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy: summary. Vox Sang. 2018;113(5):492–498. doi: 10.1111/vox.12652.

40. Dean CL, Maier CL, Chonat S, et al. Challenges in the treatment and prevention of delayed hemolytic transfusion reactions with hyperhemolysis in sickle cell disease patients. Transfusion. 2019;59(5):1698–1705. doi: 10.1111/trf.15227.

41. Padmanabhan A, Connelly-Smith L, Aqui N, et al. Guidelines on the use of therapeutic apheresis in clinical practice — evidence-based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue. J Clin Apher. 2019;34(3):171–354. doi: 10.1002/jca.21705.

42. Zhiburt EB, Madzaev SR, Shestakov EA, Vergopulo AA. Menedzhment krovi patsienta. Moscow: Pirogov National Medical & Surgical Center; 2014. (In Russ).

43. Zhiburt EB, Gubanova MN, Averyanov EG. et al. New in transfusiology (at the congress of the International Society of Blood Transfusion in Basel). Transfuziologiya. 2019;20(3): 223–236. (In Russ).

44. Gubanova MN, Kopchenko TG, Karavaev AV, et al. The system for the prevention of post-transfusion complications in the subject of the Russian Federation. Bulletin of Pirogov National Medical & Surgical Center. 2010; 5(2):97–102. (In Russ).