DOI: 10.25881/20728255_2023_18_2_29

Authors

Komarov R.N.1, Matsugnov D.A.2, Nuzhdin M.D.2, Bystrov D.O.3

1 I.M. Sechenov First Moscow State Medical University, Moscow

2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk

3 First City Clinical Hospital named E.E. Volosevich, Arkhangelsk

Abstract

Atrial flutter (Afl) is one of the most common arrhythmias, second after atrial fibrillation (AF). The «gold standard» of Afl treatment is radiofrequency ablation of the cavotricuspid isthmus (CTI). However, that is not possible in patients with AF and mitral valve disease who require open combined surgery. So, the aim of this work is to evaluate the effectiveness of performing cryoablation line on CTI as one of the stages of the “Cox-MAZE” procedure as a method of treating and preventing the development of Afl.

Aim. To evaluate the effectiveness of performing cryoablation line on CTI as one of the stages of the «Cox-MAZE» procedure as a method of treating and preventing the development of Afl.

Methods. During the period from January 2019 to December 2022, based on the Department of Cardiac Surgery of the Chelyabinsk Regional Clinical Hospital, 49 patients, with mitral valve disease and AF, who underwent biatrial Cox-maze cryoablation procedure and mitral valve surgery. Afl before surgery occurred in 16 (32.7%) patients. The primary endpoint was the assessment of the development of Afl in the postoperative period. Secondary endpoints were the development of complications in the early postoperative period (need a permanent pacemaker, stroke, surgical infection, myocardial infarction, mortality).

Results. The LA dimension was 5.4 [5.0-5.6] cm. and the RA was 5.7 [5.2–6.4] cm. The aortic cross clamping and cardiopulmonary bypass were 148 [132–164] and 190 [170–206] minutes, respectively. The ablation time for all lines was 11.0 [9.5–13.0] minutes. Sinus rhythm before discharge was restored in 46 (93.9%) patients. Afl developed in 6 (12.2%) patients in the early postoperative period. The need a permanent pacemaker — 2 (4.08%) cases.

Conclusion. According to the results of our study, the effectiveness of performing an ablation line on CTI was demonstrated. The incidence of AfL in the postoperative period was 6.8%, and for those who did not undergo a line for CTI, 60.0% (p = 0.01). The chances of developing Afl in patients with the performance this line were 20.4 times lower than in patients without line on CTI (95% CI: 2.42–166.6). There were no statistically significant differences dependence on the atrial flutter development in the postoperative period from tricuspid valve repair (p = 0.97).

Keywords: atrial flutter, atrial fibrillation, cavotricuspid isthmus cryoablation, Cox-maze procedure.

References

1. Asvestas D, Sousonis V, Kotsovolis G, et al. Cavotricuspid isthmus ablation guided by force-time integral — A randomized study. Clin Cardiol. 2022; 45(5): 503-508. doi: 10.1002/clc.23805.

2. Page RL, Joglar JA, Caldwell MA, et al. Evidence Review Committee Chair. 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2016; 133(14): e471-505. doi: 10.1161/CIR.0000000000000310.

3. Varela DL, Rosenberg MA, Borne RT, et al. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2022; 63(3): 581-589. doi: 10.1007/s10840-021-01065-0.

4. Lee R, McCarthy PM, Wang EC, et al. Midterm survival in patients treated for atrial fibrillation: a propensity-matched comparison to patients without a history of atrial fibrillation. J. Thorac. Cardiovasc. Surg. 2012; 143(6): 1341-51. doi: 10.1016/j.jtcvs.2012.02.006.

5. Bockeria LA, Shengelia LD. Treatment of atrial fibrillation. Part I. Long way to the gold standart. Annaly Aritmologii. 2014; 11(2): 64-76 (In Russ.) doi: 10.15275/annaritmol. 2014.2.1.

6. Olshansky B, Okumura K, Hess PG, Waldo AL. Demonstration of an area of slow conduction in atrial flutter.J. Am. Coll. Cardiol. 1990; 16(7): 1639-48.

7. Marcos-Alberca P, Sánchez-Quintana D, Cabrera J.A., et al. Two-dimensional echocardiographic features of the inferior right atrial isthmus: the role of vestibular thickness in catheter ablation of atrial flut-ter. Eur. Heart J. Cardiovasc. Imaging.2014; 15(1): 32-40. doi:10.1093/ehjci/jet112.

8. Celikyurt U, Knecht S, Kuehne M, Reichlin T, Muehl A, Spies F. Incidence of new-onset atrial fibrillation after cavotri-cuspid isthmus ablation for atrial flutter. Europace. 2017; 0: 1-5. doi: 10.1093/europace/euw343.

9. Lee YS, Hyun DW, Jung BC, Cho YK, Lee SH, Shin DG, et al.; KTK Cardiac Electro-physiology Working Group. Left atrial volume index as a predictor for occurrence of atrial fibrillation after ablation of typical atrial flutter. J Cardiol. 2010; 56: 348-53.

10. Ellis K, Wazni O, Marrouche N, et al. Incidence of atrial fibrillation post-cavotricuspid isthmus ablation in patients with typical atrial flutter: left-atrial size as an independent predictor of atrial fibrillation recurrence. J Cardiovasc Electrophysiol. 2007; 18: 799-802.

11. Chinitz JS, Gerstenfeld EP, Marchlinski FE, Callans DJ. Atrial fibrillation is common after ablation of isolated atrial flutter during long-term follow-up. Heart Rhythm. 2007; 4:1029-33.

For citation

Komarov R.N., Matsugnov D.A., Nuzhdin M.D., Bystrov D.O. Cavotricuspid isthmus cryoablation is as one of the main stage for the Cox-maze procedure. Bulletin of Pirogov National Medical & Surgical Center. 2023;18(2):29-32. (In Russ.) https://doi.org/10.25881/20728255_2023_18_2_29