DOI: 10.25881/BPNMSC.2019.19.25.018

Authors

Chemodanov I.G., Shestakov E.A., Zhiburt E.B.

Pirogov National Medical and Surgical Center, Moscow

Abstract

We studied the practice of using the concentrate of the prothrombin complex (PCC) in the Pirogov Center. In 2012–2018, 59 patients received PCC 71 times. It has been established that PCC is effective in preventing and correcting bleeding in patients with laboratory-proven deficiency of the prothrombin complex proteins (an increase in INR). The prophylactic administration of PCC ensured the absence of indications for transfusion of red blood cell, platelets and plasma in 67.9, 82.1 and 53.6% of patients, respectively. The effectiveness of the introduction of the PCC in men and women is no different. The reduction in INR is not different in the prophylactic and therapeutic use of PCC: 1.0±0.3 and 1.2±0.6, respectively.

Keywords: prothrombin complex concentrate, coagulopathy, blood transfusion, recipient, red blood cells, platelets, plasma, guidelines.

References

1. Bulanov A.YU. Koncentraty protrombinovogo kompleksa kak instrument strategii menedzhmenta krovi pacienta. Tromboz, gemostaz i reologiya.2017;(4):20–24. (In Russ.).

2. Gubanova MN, Mamadaliev DM, SHestakov EA, et al. Evolyuciya perelivaniya krovi v filialah Pirogovskogo centra. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova.2014;9(3):71–74. (In Russ.).

3. Gubanova MN, Serba IK, SHestakov EA, et al. Evolyuciya perelivaniya krovi v Pirogovskom centre. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova.2017;12(4): 90–92. (In Russ.).

4. ZHiburt EB. Menedzhment krovi pacienta pri kriticheskom krovotechenii i massivnoj transfuzii. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2013;8(4):71–77. (In Russ.)

5. ZHiburt EB. Pravila perelivaniya plazmy. M.: Medicina, 2008: 240 p. (In Russ.).

6. ZHiburt EB. Sluzhba krovi Pirogovskogo centra: vchera, segodnya, zavtra. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2006;1(1):55–57 (In Russ.).

7. ZHiburt EB, Gubanova MN, SHestakov EA, Ismailov HG. Potrebnost’ kliniki v komponentah krovi izmenyaetsya. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2008;3(1):60–67. (In Russ.).

8. ZHiburt EB, Madzaev SR, Kuz’min N.S., Vergopulo A.A. Gemotransmissivnye infekcii u naseleniya i donorov krovi// Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2016;11(1):88–90. (In Russ.).

9. ZHiburt EB, Madzaev SR, SHestakov EA, et al. Medicinskaya i ekonomicheskaya effektivnost’ ogranichitel’noj strategii perelivaniya krovi. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2015;10(1):100–102. (In Russ.).

10. ZHiburt EB, SHestakov EA, Vergopulo AA. Pervyj opyt audita transfuzij svezhezamorozhennoj plazmy // Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2009;4(1):20–23. (In Russ.).

11. ZHiburt EB, SHestakov EA, Lihonin DA, Karavaev AV. Perelivanie plazmy zhenshchin povrezhdaet legkie recipient. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2011;6(2):109–111. (In Russ.).

12. Madzaev SR, SHestakov EA, Kozhevnikov AS, et al. Polimorfizm perelivaniya krovi v filialah Pirogovskogo centra// Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I.Pirogova. 2013;8(2):91–93. (In Russ.).

13. Prasolov NV, Bulanov AYu, SHulutko EM, et al. Kompleksnaya terapiya tyazhelogo poslerodovogo krovotecheniya s ispol’zovaniem koncentrata protrombinovogo kompleksa. Tromboz, gemostaz i reologiya. 2018;(4):36–43. (In Russ.).

14. Rybka MM, Samsonova NN, Klimovich LG, et al. Korrekciya gemostaza preparatami krovi pri hirurgicheskom lechenii vrozhdennyh porokov serdca u novorozhdennyh i detej rannego vozrasta// Anesteziologiya i reanimatologiya. 2015;60(5):42–46. (In Russ.).

15. CHemodanov IG, Gorelikova LG, Lyackovskii AI, et al. Instrument profilaktiki transfuzionnoi cirkulyatornoi peregruzki.Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2018;13(4): 93–95. (In Russ.).

16. SHevchenko YuL, ZHiburt EB, SHestakov EA. Vnedrenie krovesberegayushchej ideologii v praktiku Pirogovskogo centra. Vestnik Nacional’nogo mediko-hirurgicheskogo centra im. N.I. Pirogova. 2008;3(1):14–21. (In Russ.).

For citation

Chemodanov I.G., Shestakov E.A., Zhiburt E.B. Protrombin complex concentrate in coagulopathy prevention and treatment. Bulletin of Pirogov National Medical & Surgical Center. 2019;14(3):87-89. (In Russ.) https://doi.org/10.25881/BPNMSC.2019.19.25.018